CBD Oil for Pain – 9 Amazing Mechanisms Explained

CBD Oil for Pain – 9 Amazing Mechanisms Explained

CBD Oil for Pain

CBD oil has gained immense popularity for its potential to alleviate pain. Understanding how it works can help individuals make informed decisions about its use. This guide delves into nine amazing mechanisms by which CBD oil can relieve pain, shedding light on its multifaceted approach to pain management.

1. Interaction with the Endocannabinoid System (ECS)

The ECS is a complex cell-signaling system present throughout the body that plays a crucial role in regulating various functions, including pain perception. CBD interacts with cannabinoid receptors (CB1 and CB2) in the ECS, modulating pain signals. By influencing these receptors, CBD can help reduce the intensity of pain signals sent to the brain, leading to pain relief.

2. Anti-Inflammatory Properties

Inflammation is a common cause of pain, particularly in conditions like arthritis and injuries. CBD oil has potent anti-inflammatory properties that help reduce inflammation at the source. It inhibits the production of inflammatory cytokines and mediators, thereby reducing swelling and pain. This makes CBD oil effective for managing inflammatory conditions and related pain.

3. Reduction of Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body, leading to tissue damage and pain. CBD is a powerful antioxidant that helps neutralize free radicals, reducing oxidative stress. By protecting tissues from oxidative damage, CBD can alleviate pain associated with various chronic conditions.

4. Modulation of Serotonin Receptors

Serotonin is a neurotransmitter that plays a role in mood and pain regulation. CBD interacts with serotonin receptors, particularly the 5-HT1A receptor, which can influence pain perception and mood. This interaction not only helps alleviate pain but also improves mood, which can further enhance pain management by reducing the emotional impact of chronic pain.

5. Inhibition of Pain Pathways

CBD can inhibit pain pathways in the central nervous system. It modulates the activity of neurons involved in pain transmission, reducing their excitability and the overall perception of pain. This mechanism is particularly beneficial for neuropathic pain, where traditional painkillers often fall short. By targeting specific pain pathways, CBD provides targeted relief.

6. Muscle Relaxation

Muscle tension and spasms can contribute to pain, particularly in conditions like fibromyalgia and multiple sclerosis. CBD has muscle-relaxing properties that help reduce muscle tension and spasms. By relaxing muscles, CBD alleviates pain and improves mobility, providing significant relief for individuals with muscle-related pain conditions.

7. Enhancement of Natural Painkillers

CBD can enhance the effects of natural painkillers in the body, such as anandamide, often referred to as the “bliss molecule.” CBD inhibits the enzyme FAAH (fatty acid amide hydrolase), which breaks down anandamide. By preventing its breakdown, CBD increases the levels of anandamide in the body, enhancing its natural pain-relieving effects.

8. Improvement of Sleep Quality

Chronic pain often interferes with sleep, leading to a vicious cycle of pain and sleep deprivation. CBD has sedative properties that can improve sleep quality and duration. Better sleep helps the body heal and recover, reducing overall pain levels. By promoting restful sleep, CBD indirectly contributes to pain relief and enhances overall well-being.

9. Emotional and Psychological Relief

Chronic pain can take a toll on mental health, leading to anxiety, depression, and stress. CBD’s anxiolytic and antidepressant effects help manage these emotional and psychological aspects of pain. By reducing anxiety and improving mood, CBD helps individuals cope better with chronic pain, leading to a more holistic approach to pain management.


CBD oil offers a comprehensive approach to pain relief through multiple mechanisms. By interacting with the ECS, reducing inflammation and oxidative stress, modulating serotonin receptors, inhibiting pain pathways, relaxing muscles, enhancing natural painkillers, improving sleep quality, and providing emotional relief, CBD addresses pain from various angles. This multifaceted approach makes CBD oil a promising option for individuals seeking natural and effective pain management. Always consult with a healthcare provider before starting any new treatment to ensure it is appropriate for your specific condition and needs. With its broad range of benefits, CBD oil is poised to play a significant role in pain management strategies.

Expert recommendation

If you’re searching for a high quality, 100% natural and pure, pesticide-free, preservatives-free and non-GMO Full Spectrum 10% CBD Oil, we have the perfect product for you.

At Favoroot, we believe that you and your loved ones deserve only the best – that’s why our range of Premium CBD Oil is:

🌱fully certified
🌱100% natural
🌱pesticide free
🌱additives free
🌱preservatives free
🌱lab tested
🌱microbiology clean
🌱heavy metals free

We use black glass bottles with natural bamboo dripper caps for the most elegant and natural look. The beautiful design and the high quality make Favoroot CBD Oil an ideal gift for your loved ones!

Click here to read more about the Favoroot Full Spectrum CBD Oil Drops 10%

More inspiration

Best of luck in your journey to wellness! If you have any further questions about CBD oil, please don’t hesitate to reach out. We’re here to help.

Follow Favoroot on instagram and facebook for daily inspiration, expert tips and special discounts!


  1. Russo, E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management, 4(1), 245–259.
  2. Baron, E. P. (2018). Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache: The Journal of Head and Face Pain, 58(7), 1139–1186.
  3. Capano, A., Weaver, R., & Burkman, E. (2019). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgraduate Medicine, 131(1), 38–48.
  4. Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain, 20(6), 936–948.
  5. Babson, K. A., Sottile, J., & Morabito, D. (2017). Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current Psychiatry Reports, 19(4), 23.
  6. Hurd, Y. L., Yoon, M., Manini, A. F., Hernandez, S., Olmedo, R., Ostman, M., & Jutras-Aswad, D. (2015). Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage. Neurotherapeutics, 12(4), 807–815.
  7. Rahn, E. J., & Hohmann, A. G. (2009). Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside. Neurotherapeutics, 6(4), 713–737.
  8. Zgair, A., Wong, J. C., Lee, J. B., Mistry, J., Sivak, O., Wasan, K. M., Hennig, I. M., Barrett, D. A., & Constantinescu, C. S. (2016). Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American Journal of Translational Research, 8(8), 3448–3459.
  9. National Institute on Drug Abuse. (2021). Cannabis (Marijuana) and Cannabinoids: What You Need To Know. Retrieved from https://www.drugabuse.gov/publications/drugfacts/marijuana.
  10. World Health Organization. (2018). Cannabidiol (CBD) Pre-Review Report. Expert Committee on Drug Dependence, Fortieth Meeting. Geneva, 4-7 June 2018.
  11. Food and Drug Administration. (2021). FDA Regulation of Cannabis and Cannabis-Derived Products: Questions and Answers. Retrieved from https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd.
  12. Huestis, M. A. (2007). Human Cannabinoid Pharmacokinetics. Chemistry & Biodiversity, 4(8), 1770–1804.
  13. Millar, S. A., Stone, N. L., Yates, A. S., & O’Sullivan, S. E. (2018). A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in Pharmacology, 9, 1365.
  14. Morales, P., & Reggio, P. H. (2017). The Endocannabinoid System: A Target for the Treatment of Pain and Inflammation. Medicines, 4(3), 63.
  15. Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., Prostran, M., & Tufegdžić, S. (2018). Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in Pharmacology, 9, 1259.
  16. Abnosi, M. H., Rahmanian, M., Mostafavinia, A., Amini-Khoei, H., Hamidian, G., & Afshari, K. (2018). Antinociceptive Effect of Cannabinoids in the Brain: Pharmacological Mechanisms, Animal Models, and Future Challenges. Journal of Chemical Neuroanatomy, 89, 1–24.
  17. Schuelert, N., & McDougall, J. J. (2011). Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. Arthritis and Rheumatism, 63(12), 3888–3897.
  18. Häuser, W., Fitzcharles, M. A., Radbruch, L., Petzke, F. J., & Sommer, C. (2017). Cannabinoids in Pain Management and Palliative Medicine. Deutsches Ärzteblatt International, 114(38), 627–634.
  19. Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S. R., Willenbring, D., Guan, Y., Pan, H. L., Ren, K., Xu, Y., Zhang, L., & Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209(6), 1121–1134.
  20. Ligresti, A., Moriello, A. S., Starowicz, K., Matias, I., Pisanti, S., De Petrocellis, L., Laezza, C., Portella, G., Bifulco, M., & Di Marzo, V. (2006). Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. Journal of Pharmacology and Experimental Therapeutics, 318(3), 1375–1387.

Leave a Reply

Your email address will not be published. Required fields are marked *